![]() ![]() Four rabbits in group 2 were subjected, 1 hr after return to CMV from ITPV, to another session of ITPV, with positive end-expiratory pressure gradually being increased to 4, 6, and 8 cm H2O for 15 mins each. Six rabbits were ventilated at 30 breaths/min (group 1), and ten rabbits were ventilated at 80 breaths/min (group 2). After lung injury, all animals were consecutively ventilated for 1 hr with CMV, for 1 hr with ITPV, and again for 1 hr with CMV. Carinal positive end-expiratory pressure was maintained at a constant value of 2 cm H2O by adjusting the expiratory resistance of the ventilator circuit Lung injury was achieved over a 30-min period by three normal saline lavages of 5 mL/kg each. ITPV was established using a flow of 1.0 L/kg/min through a reverse thrust catheter, at the same baseline and inspiratory/expiratory ratio. A normal baseline for arterial blood gases was achieved by adjusting the inspiratory/expiratory time ratios. The pressure limit of the ventilator was effectively disabled. CMV was initiated with a pressure-limited, time-cycled ventilator set at an FiO2 of 1.0 and at a flow of 1.0 L/kg/min. To prevent obstruction of the port, it was flushed with oxygen at a rate of 11 mL/min. The injection port of the multilumen endotracheal tube was used for the carinal pressure monitoring. Proximal airway pressures and carinal pressures were recorded continuously. Anesthesia and muscle relaxation were maintained continuously throughout the study. ![]() proximal airway pressures, and gas exchange efficacy with a constant minute volume, in lung-injured rabbits during conventional mechanical ventilation (CMV) and intratracheal pulmonary ventilation (ITPV) and to evaluate performance of a prototype ITPV gas delivery and continuous airway pressure monitoring system.Īnimal research laboratory at a teaching hospital.Īnesthetized rabbits were tracheostomized with a multilumen endotracheal tube. ![]()
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